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²Î¿¼ÎÄÏ×
[1]Hu SXC, Yang P, Huang X. An epidemiological survey of uveitis in Southern China. 2002; 2: 1-3.
[2]Zheng Y, Zhang LX, Meng QL, Zhang M, Cui Y, Liu QY, et al. Clinical patterns and characteristics of uveitis in a secondary hospital in southern China. Int J Ophthalmol. 2015;8:337¨C41.?
[3]Yang P, Zhang Z, Zhou H, Li B, Huang X, Gao Y, et al. Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China. Curr Eye Res. 2005;30:943¨C8.?
[4]Gao F, Zhao C, Cheng G, Pei M, Liu X, Wang M, et al. Clinical patterns of uveitis in a tertiary center in north China. Ocul Immunol Inflamm. 2017;25(sup1):S1¨CS7
[5]Hale S, Lightman S. Anti-TNF therapies in the management of acute and chronic uveitis. Cytokine. 2006;33:231-237.
[6]Jaffe G.J. et al, Adalimumab in Patients with Active Noninfectious Uveitis, N Engl J Med 2016;375:932-43.